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Tel: (202) 334-3543
Email: paro@nas.edu
Project Information

Project Information


Opportunities and Approaches for Supplying Molybdenum-99 and Associated Medical Isotopes to Global Markets: A Symposium


Project Scope:

The U.S. National Academies of Sciences, Engineering, and Medicine (the National Academies) and the Russian Academy of Sciences will organize a joint symposium to discuss opportunities and approaches for supplying molybdenum-99 (Mo-99) and associated medical isotopes (iodine-131 and xenon-133) to global markets. The symposium will address the following topics: 

  • Trends in global demand and supply for Mo-99 and associated medical isotopes.
  • Prospects and approaches for developing new global supplies of Mo-99 and associated medical isotopes.
  • Technical, regulatory, economic, and policy considerations for producing Mo-99 and associated medical isotopes for global markets using uranium-fission and other processes. 

The symposium presentations and discussions will be summarized in a National Academies proceedings that will be issued in English and Russian.

 

Status: Current

PIN: DELS-NRSB-16-03

Project Duration (months): 14 month(s)

RSO: Kosti, Ourania

Board(s)/Committee(s):

Nuclear and Radiation Studies Board

Topic(s):

Conflict and Security Issues
Engineering and Technology
Health and Medicine
Math, Chemistry, and Physics
Policy for Science and Technology


Committee Membership

Committee Post Date: 03/01/2017

Dr. Hedvig Hricak - (Chair)
CHAIR

Hedvig Hricak, MD, (NAM) is Chairman of the Department of Radiology at Memorial Sloan-Kettering Cancer Center. In addition to holding a senior position within the Program of Molecular and Pharmacology Therapeutics at the Sloan-Kettering Institute, she is a professor at Gerstner Sloan-Kettering Graduate School of Biomedical Sciences and a professor of radiology at the Weill Medical College of Cornell University. She has helped develop applications in ultrasound, magnetic resonance (MR), and computed tomography for gynecological cancers as well as MR and MR spectroscopy for prostate cancer. She continues to investigate diagnostic methods for cancer detection, staging, and management and is involved in developing clinical approaches for molecular imaging of cancer. She is a member of the National Academy of Medicine and a foreign member of both the Russian Academy of Science and the Croatian Academy of Arts and Sciences. In recognition of her career accomplishments, she has received the Marie Curie Award of the American Association of Women Radiologists (2003), the gold medals of the International Society for Magnetic Resonance in Medicine (2003) and the Association of University Radiologists, the Béclère medal of the International Society of Radiology (2007), the Morocco Medal of Merit (2008), and the Katarina Zrinska Croatian presidential award (2009). In 2005 she was awarded an honorary doctorate in medicine (Dr.h.c.) from Ludwig Maximilian University in Munich, Germany. She has previously served on numerous committees and on the Nuclear and Radiation Studies Board of the National Academies. She earned her MD degree from the University of Zagreb and her Dr. Med. Sc. from the Karolinska Institute.
Mr. Jack L. Coffey
Jack L. Coffey, CHP, serves as a consultant with Lachman Consulting Services to radiopharmaceutical developers and manufacturers with primary emphasis on supplier and manufacturing site qualification, Food and Drug Administration compliance, and manufacturing process improvements. He is also a member of the Board of Directors of Enigma Biomedical Group. He has ten years of research experience in medical isotope and radiopharmaceutical production followed by over 20 years of commercial company experience in medical isotope production and radiopharmaceutical supply. His experience at Cardinal Health Nuclear Pharmacy Services (2003-2012) and Syncor International Corporation (1984-2003) has included regulatory compliance auditing, quality and regulatory affairs management, as well as serving as an officer of a publicly held corporation. As a scientist at Oak Ridge Associated Universities (1974-1984), Mr. Coffey conducted radiopharmaceutical research focused specifically on determining radiation doses to patients and members of the public. Mr. Coffey chaired the Council on Radionuclides and Radiopharmaceuticals (CORAR) from 2011-2012 and is a member of the Health Physics Society, and American Academy of Health Physics. He received a BS in chemistry and biology from the University of the Cumberlands and an MS in radiation biology at the University of Tennessee.




Dr. Eugene J. Peterson
Eugene J. Peterson, Ph.D., is executive advisor to Los Alamos National Laboratory’s associate director for chemistry, life, and earth sciences and is leading the laboratory’s strategic planning efforts for the Science of Signatures Science Pillar. Previously, he was the chemistry division leader at Los Alamos, where he was responsible for 350 chemical professionals and a budget of approximately $150 million. Before his tenure as chemistry division leader, Dr. Peterson specialized in medical isotope production and applications research and development. He was responsible for technical management of the laboratory’s isotope production efforts and associated research and development, business management of isotope distribution and marketing, and procuring adequate funding for these programs. Notable program successes during his tenure included the construction of a new $23.5 million 100 MeV Isotope Production Facility at the Los Alamos Neutron Science Center for the production of accelerator isotopes and the lease by the Department of Energy of the laboratory’s cryogenic distillation columns for the separation and purification of isotopes of carbon, nitrogen, and oxygen to the private sector. Dr. Peterson served on the National Academies Committee on Medical Isotope Production without Highly Enriched Uranium (2007-2009) and the Committee on the State of Molybdenum-99 Production and utilization and Progress toward Eliminating Use of Highly Enriched Uranium (2014-2016). He received his B.S. degree from the Illinois Benedictine College and his Ph.D. degree in inorganic chemistry from Arizona State University.

Events



Location:

Moscow, Russia
Event Type :  
-

Registration for Online Attendance :   
NA

Registration for in Person Attendance :   
NA


If you would like to attend the sessions of this event that are open to the public or need more information please contact

Contact Name:  Toni G Greenleaf
Contact Email:  tgreenle@nas.edu
Contact Phone:  2023343066

Agenda
We distributed the English and Russian versions of the report to the committee members during that closed session.
Is it a Closed Session Event?
Yes

Closed Session Summary Posted After the Event

The following committee members were present at the closed sessions of the event:

Dr. Stepan Kalmykov
Dr. Sergey Vladimirovich Yudintsev
Dr. Boris L. Zhuikov
Dr. Sci
Dr. Boris Myasoedov
Yuri Konstantinovich Shiyan


The following topics were discussed in the closed sessions:

Russian version of the report and when it will be finalized for printing.

The following materials (written documents) were made available to the committee in the closed sessions:

NONE

Date of posting of Closed Session Summary:
November 17, 2017


Location:

Keck Center
500 5th St NW, Washington, DC 20001
Event Type :  
-

Registration for Online Attendance :   
NA

Registration for in Person Attendance :   
NA


If you would like to attend the sessions of this event that are open to the public or need more information please contact

Contact Name:  Rania Kosti
Contact Email:  okosti@nas.edu
Contact Phone:  (202) 334-3066

Is it a Closed Session Event?
Yes

Closed Session Summary Posted After the Event

The following committee members were present at the closed sessions of the event:

Hedi Hricak
Gene Peterson
Jack Coffey

The following topics were discussed in the closed sessions:

Draft of report

The following materials (written documents) were made available to the committee in the closed sessions:

None

Date of posting of Closed Session Summary:
October 13, 2017


Location:

International Atomic Energy Agency
Board Room A
M Building
Vienna International Centre
PO Box 100, 1400 Vienna, Austria

Event Type :  
-

Registration for Online Attendance :   
NA

Registration for in Person Attendance :   
NA


If you would like to attend the sessions of this event that are open to the public or need more information please contact

Contact Name:  Rania Kosti
Contact Email:  okosti@nas.edu
Contact Phone:  (202) 334-3066

Agenda
Opportunities and Approaches for Supplying Molybdenum-99 and Associated Medical Isotopes to Global Markets


Symposium Day 1: Monday, July 17, 2017

International Atomic Energy Agency
Board Room A
M Building
Vienna International Centre
PO Box 100, 1400 Vienna, Austria



9:00 Opening Session

Welcome
? Meera Venkatesh, International Atomic Energy Agency (5’)
? Christophe Xerri, International Atomic Energy Agency (5’)

Statement from the US and Russian Academies
Stepan Kalmykov, co-chair, Russian Academy of Sciences (on behalf of the symposium organizing committees) (10’)

9:20 Plenary Session
Moderator: Alexander Bychkov, Permanent Mission of the Russian Federation to the International Organizations in Vienna

Mo-99 production: past, present, and future
Hedvig Hricak, co-chair, U.S. National Academies (on behalf of the symposium organizing committees) (10’)

Russia’s role in global molybdenum-99 supply
Alexey Vakulenko, JSC V/O IZOTOP, Russian Federation (20’)

Establishing and expanding nuclear medicine programs
? Rodolfo Nunez-Miller, International Atomic Energy Agency (10’)
? Wolfgang Weber, Memorial Sloan Kettering, United States (10’)

Plenary session discussion (15’)


10:30

BREAK

10:50 Molybdenum-99 Supply Reliability: Session 1
Moderator: Jack Coffey, Enigma Biomedical Group

Organisation for Economic Co-operation and Development-Nuclear Energy Agency’s principles to address molybdneum-99 supply reliability and the organization’s global market demand and production capacity projections
Kath Smith, High-level Group on the Security of Supply of Medical Radioisotopes (15’)

The European Commission’s efforts to evaluate the supply of medical radioisotopes
Margarida Goulart, European Commission (15’)

Reactor schedule coordination for molybdenum-99 supply reliability
Bernard Ponsard, AIPES Reactors & Isotopes Working Group (15’)

Investments in AREVA’s target production facility to improve long term sustainable security of molybdneum-99 supply
Yann Guinard, AREVA, France (15’)

Session 1 discussion (20’)

12:10 Molybdenum-99 Supply: Session 2 (part 1)
Moderator: Rania Kosti, U.S. National Academies

Existing global suppliers: current production and future plans
? Roy Brown, Curium (10’)
? Michael Druce, ANSTO, Australia (10’)
? Gavin Ball, NTP, South Africa (10’)
? Jean-Michel Vanderhofstadt, IRE, Belgium (10’)


12:50

LUNCH

14:30 Molybdenum-99 Supply: Session 2 (part 2)
Moderator: Rania Kosti, U.S. National Academies

New projects for regional or global molybdenum-99 supply
? James Harvey, NorthStar, United States (10’)
? Katrina Pitas, SHINE, United States (10’)
? Carolyn Haass, Northwest Medical Isotopes, LLC, United States (10’)
? Carmen Bigles, Coquí Radio Pharmaceuticals, United States (10’)
? Matthew Lish, Flibe Energy, United States (10’)
? Hermen van der Lugt, PALLAS Reactor, Netherlands (10’)
? Oleg Kononov, Karpov Scientific Research Institute of Physics and Chemistry, Russian Federation (10’)
? Ken Buckley, TRIUMF, Canada (10’)
? Kennedy Mang’era, Canadian Isotope Innovations Corp. (10’)
? Jin Du, China Isotope & Radiation Corporation (10’)
? Anupam Mathur, Department of Atomic Energy, India (10’)
? Ul-Jae Park, Korea Atomic Energy Research Institute (10’)
? Pablo Cristini, National Atomic Energy Commission, Argentina (10’)
? Mostafa Abd Elaal, Egyptian Atomic Energy Authority (10’)


Session 2 discussion (30’)

17:30 Late afternoon break and closing remarks
(Participants move to MO2 Foyer)


19:30

Adjourn symposium day 1



Symposium Day 2: Tuesday, July 18, 2017

Location
International Atomic Energy Agency
Board Room A
M Building
Vienna International Centre
PO Box 100, 1400 Vienna, Austria


9:00 Welcome
Stepan Kalmykov, co-chair, Russian Academy of Sciences committee (on behalf of the two Academies) (5’)

9:05 Technical Considerations : Session 3
Moderator: Boris Zhuikov, Russian Academy of Sciences

Conversion to low enriched uranium-based molybdenum-99 production
? Jean-Michel Vanderhofstadt, IRE, Belgium (10’)
? Roy Brown, Curium (10’)
? Gavin Ball, NTP, South Africa (10’)
? Vladimir Risovaniy, Rosatom, Russian Federation (10’)

Production expansion
Michael Druce, ANSTO, Australia (10’)

Prospects for the use of activation of molybdenum for the production of technetium-99m generators
Victor Skuridin, Tomsk Polytechnic University, Russian Federation (15’)

High-density low enriched uranium targets production
? Bertrand Stepnik, AREVA, France (15’)
? Kinam Kim, Korea Atomic Energy Research Institute (15’)

Session 3 discussion (20’)


11:40

BREAK

12:00 Regulatory Considerations: Session 4
Moderator: Joao Alberto Osso Junior, International Atomic Energy Agency

European Medicines Agency’s regulatory considerations
Brendan Cuddy, European Medicines Agency (20’, pre-recorded)

Perspectives from Tc-99m generator manufacturers
? Ira Goldman, Lantheus Medical Imaging, United States (10’)
? Roy Brown, Curium, Netherlands (10’)

Perspectives from a nuclear pharmacy
David Pellicciarini, Cardinal Health, United States (15’)

Session 4 discussion (15’)

13:15
LUNCH


14:30 Economic Considerations: Session 5
Moderator: Charles Ferguson, Federation of American Scientists

Molybdenum-99 supply economics
Jan Willem Velthuijsen, PwC Europe (20’)

Low enriched uranium-based molybdenum-99 production
? Gavin Ball, NTP (5’)
? Michael Druce, ANSTO (5’)

Session 5 discussion (25’)


15:30

BREAK




15:50 Chemical Processing and Waste Management: Session 6
Moderator: Sergey Yudintsev, Russian Academy of Sciences

Chemical processing and waste management following neutron activation
Engeniy Nesterov, Tomsk Polytechnic University, Russian Federation (10’)

Development of a novel dry chemical uranium molybdenum separation: Research for a future efficient Mo-99 extraction process
Riane Stene, FRM-II, Germany (10’)

Waste management in HEU versus LEU-based molybdenum-99 production
Jean-Michel Vanderhofstadt, IRE, Belgium (15’)

Synroc Technology for the Management of molybdenum-99 Waste
Bruce Begg, ANSTO, Australia (10’)

Recycling processed LEU for reuse as target material
Carolyn Haass, Northwest Medical Isotopes, LLC, United States (10’)

Session 6 discussion (30’)

17:20 Closing remarks
Hedi Hricak, co-chair, US National Academies
Stepan Kalmykov, co-chair, Russian Academy of Sciences


17:30

Adjourn symposium











Invited Briefing and Tour: Wednesday, July 19, 2017

Location
International Atomic Energy Agency
TBD
Vienna International Centre (VIC)
PO Box 100, 1400 Vienna, Austria



11:30 – 12:30
IAEA activities in nuclear energy and applications
Meera Venkatesh, International Atomic Energy Agency
Christophe Xerri, International Atomic Energy Agency


12:30 – 13:10

LUNCH


13:15
Depart for IAEA laboratories in Seibersdorf*
Meeting location for departure TBD.
Arrive on time to avoid missing the bus which will depart at 13:15 promptly.
*Registration for the tour is now closed.


14:00 – 16:00

Tour of the IAEA laboratories in Seibersdorf


16:45

Return to VIC


Internet Access:

Public access WiFi is available throughout the IAEA buildings. Select access point wlan-guest and the connection will be automatic; there is no password.

Is it a Closed Session Event?
No



Location:

Moscow State University, Russia
Event Type :  
-

Registration for Online Attendance :   
NA

Registration for in Person Attendance :   
NA


If you would like to attend the sessions of this event that are open to the public or need more information please contact

Contact Name:  Ourania Kosti
Contact Email:  okosti@nas.edu
Contact Phone:  (202) 334-3066

Agenda
April 10, 2017: ~2 PM – 6 PM

• Welcome remarks. Dr. Stepan Kalmykov, RAS committee chair and Dr. Hedi Hricak, NAS committee chair
• Remarks on the joint US and Russian Academies study, Vladimir D. Risovany, Rosatom
• The Joint U.S. and Russian Academies study request and an overview of the U.S. Mo-99 Program. Dr. Jeff Chamberlin, U.S. Department of Energy
• The 2016 NAS report on Molybdnenum-99 for medical imaging. Dr. Kevin Crowley, 2016 NAS report study director
• Overview of current Mo-99 production in Russia, Boris Zhuikov, Institute for Nuclear research, RAS

April 11, 2017: ~ 10:30 AM – 1 PM

• Plans for expansion of Mo-99 production n Russia, Stepan Kalmykov on behalf of Rostislav Kuznetsov, Rosatom
• Plans for expansion of Mo-99 production in Russia: Activation Tc-99m Viktor Skuridin, Tomsk PU
• Mo-99 demand in Russia: demand on Tc-99m generators and kits, Galina Kodina, FMBA

Is it a Closed Session Event?
Yes

Closed Session Summary Posted After the Event

The following committee members were present at the closed sessions of the event:

Hedi Hricak
Jack Coffey

The following topics were discussed in the closed sessions:

agenda for symposium

The following materials (written documents) were made available to the committee in the closed sessions:

None

Date of posting of Closed Session Summary:
April 13, 2017


Location:

Conference call
Event Type :  
-

Registration for Online Attendance :   
NA

Registration for in Person Attendance :   
NA


If you would like to attend the sessions of this event that are open to the public or need more information please contact

Contact Name:  Ourania Kosti
Contact Email:  okosti@nas.edu
Contact Phone:  (202) 334-3066

Is it a Closed Session Event?
Yes

Closed Session Summary Posted After the Event

The following committee members were present at the closed sessions of the event:

Hedi Hricak
Gene Peterson
Jack Coffey

The following topics were discussed in the closed sessions:

statement of task
visit to Moscow


The following materials (written documents) were made available to the committee in the closed sessions:

None

Date of posting of Closed Session Summary:
March 20, 2017


Location:

Conference call
Event Type :  
-

Registration for Online Attendance :   
NA

Registration for in Person Attendance :   
NA


If you would like to attend the sessions of this event that are open to the public or need more information please contact

Contact Name:  Ourania Kosti
Contact Email:  okosti@nas.edu
Contact Phone:  (202) 334-3066

Is it a Closed Session Event?
Yes

Closed Session Summary Posted After the Event

The following committee members were present at the closed sessions of the event:

Hedi Hricak
Gene Peterson
Jack Coffey

The following topics were discussed in the closed sessions:

statement of task
study schedule

The following materials (written documents) were made available to the committee in the closed sessions:

statement of task
study schedule
committee member bios

Date of posting of Closed Session Summary:
March 10, 2017

Publications