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Tel: (202) 334-3543
Email: paro@nas.edu
Project Information

Project Information


Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens


Project Scope:

A committee of the National Research Council will conduct a scientific peer review of the formaldehyde assessment presented in the National Toxicology Program (NTP) 12th Report on Carcinogens (RoC).  The committee will identify and evaluate relevant, publicly available, peer-reviewed literature, with particular emphasis on literature published as of June 10, 2011, the release date of the 12th RoC.  The committee will document its decisions for inclusion or exclusion of literature from its evaluation and will identify the set of information deemed most critical to the evaluation.  The committee will apply independently the NTP’s established RoC listing criteria to the scientific evidence from studies in humans, experimental animals, and other studies relevant to mechanisms of carcinogenesis and make independent level-of-evidence determinations with respect to the human and animal studies.  The committee will integrate the level-of-evidence conclusions, and considering all relevant information in accordance with the RoC listing criteria, make an independent listing recommendation for formaldehyde and provide scientific justification for its recommendation.
 
Note: The NRC has an agreement with the Department of Health and Human Services to undertake a scientific peer review of the determinations concerning formaldehyde and styrene in the National Toxicology Program’s 12th Report on Carcinogens (RoC).  The expert committees appointed by the Academy for this assignment will follow standard Academy practices in carrying out their independent scientific reviews, which may include consideration of any and all issues that the committees and the Academy decide are necessary to carry out credible, independent, scientific evaluations of the two determinations, potentially including the criteria for the determinations. The statements of task for these two peer reviews were recently modified to make it clear that the NRC’s assignment does not also include a separate review of the National Toxicology Program’s listing criteria.

Status: Completed

PIN: DELS-BEST-12-04

Project Duration (months): 24 month(s)

RSO: Murray-Smith, Heidi

Topic(s):

Environment and Environmental Studies



Geographic Focus:

Committee Membership

Committee Post Date: 01/10/2013

Alfred O. Berg - (Chair)
University of Washington School of Medicine

Alfred O. Berg (Chair) is a professor in the Department of Family Medicine at the University of Washington. His research interests are centered around evidence-based research and policy in family medicine, including the development and use of clinical practice guidelines as practice and teaching tools. Dr. Berg has served on many national expert panels using evidence-based methods to guide practice and policy, including chair of the United States Preventive Services Task Force, co-chair of the Otitis Media Panel convened by the Agency for Health Care Policy and Research, chair of the U.S. Centers for Disease Control and Prevention (CDC) Sexually Transmitted Disease Treatment Guidelines Panel, and member of the American Medical Association/CDC panel producing Guidelines for Adolescent Preventive Services. He currently chairs the CDC Panel on Evaluation of Genomic Applications in Practice and Prevention and the National Institutes of Health State-of-the-Science Conference on Family History and Improving Health. Dr. Berg is a member of the Institute of Medicine and has served as a member and chair of several National Academies committees. He is currently a member of the Committee on Governance and Financing of Graduate Medical Education and the Committee on the Assessment of Studies of Health Outcomes Related to the Recommended Childhood Immunization Schedule. Dr. Berg earned an MD from Washington University in St. Louis, Missouri.
John C. Bailar, III
The University of Chicago

John C. Bailar III is an emeritus professor of the University of Chicago. His research interests have included trends in cancer, assessing health risks, such as the risks of new chemicals, and misconduct in science. His areas of expertise include statistics, biostatistics, epidemiology, and environmental and occupational hazards. Dr. Bailar worked at the National Cancer Institute for 22 years, and he has held academic appointments at Harvard University, McGill University, and the University of Chicago. For 11 years, he was the statistical consultant and a member of the editorial board for The New England Journal of Medicine. He was a MacArthur Fellow from 1990 to 1995, and was elected to both the Institute of Medicine and the International Statistical Institute. Dr. Bailar has served as a member and as chair of many National Academies committees. His most recent committee work has included participation in the Committee on the Analysis of Cancer Risks in Populations Near Nuclear Facilities – Phase I and the Committee to Review Possible Toxic Effects from Past Environmental Containment at Fort Detrick. Dr. Bailar earned an MD from Yale and a PhD in statistics from American University.
A. Jay Gandolfi
University of Arizona

A. Jay Gandolfi recently completed a position as Associate Dean for Research and Graduate Studies at the University of Arizona and is now a professor emeritus. His research interests include the molecular and cellular mechanisms of toxicity. His most recent studies have concentrated on the use of in vitro systems to evaluate cell specific injury, including the effects of low-level metal exposure on cell signaling and gene expression and the development of in vitro models to reflect in vivo toxicity. Tissues of interest are the liver, kidney, bladder, and prostate. Dr. Gandolfi earned a PhD in biochemistry and biophysics at Oregon State University.

David Kriebel
University of Massachusetts

David Kriebel is a professor and chair of the Department of Work Environment at the University of Massachusetts, Lowell. He is also co-director of the Lowell Center for Sustainable Production. Dr. Kriebel’s research focuses on the epidemiology of occupational injuries, cancer, and non-malignant respiratory disease. He has published on various aspects of epidemiologic methods, particularly on the use of quantitative exposure data in epidemiology. He has been active in developing dosimetric models to better understand the effects of aerosols on the lungs. He teaches introductory and advanced courses in epidemiology, risk assessment, and research synthesis. Dr. Kriebel has served on several National Academies committees, including the Committee on Beryllium Alloy Exposures and the Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides. Dr. Kriebel received an ScD in epidemiology from Harvard School of Public Health.
John B. Morris
University of Connecticut

John B. Morris is the Board of Trustees Distinguished Professor, a professor of pharmacology and toxicology, and Assistant Dean for Research in the Department of Pharmaceutical Sciences at the University of Connecticut School of Pharmacy. His research focuses on toxicity of inhaled irritant vapors, irritants and asthma, regional uptake and metabolism of inspired vapors, physiologically based pharmacokinetic modeling, and risk assessment. Dr. Morris has served on the editorial boards for Toxicological Sciences and Inhalation Toxicology and on advisory panels for the National Institutes of Health, the U.S. Environmental Protection Agency, and the Department of Energy. He has also served as a member of the National Research Council Committee on Emergency and Continuous Exposure Guidance Levels for Selected Submarine Contaminants. Dr. Morris earned a PhD in toxicology from the University of Rochester.
Kent E. Pinkerton
University of California, Davis

Kent E. Pinkerton is a professor in the Department of Pediatrics in the School of Medicine and the Department of Anatomy, Physiology, and Cell Biology in the School of Veterinary Medicine at the University of California, Davis. He also serves as director of the university's Center for Health and the Environment. His research interests focus on the health effects of environmental air pollutants on lung structure and function, the interaction of gases and airborne particles within specific sites and cell populations of the lungs in acute and chronic lung injury, and the effects of environmental tobacco smoke on lung growth and development. Dr. Pinkerton has served as a member of the National Research Council Committee on Estimating Mortality Risk Reduction Benefits from Decreasing Tropospheric Ozone Exposure and the Committee for Review of the Army’s Enhanced Particulate Matter Surveillance Project Report. Dr. Pinkerton received a PhD in pathology from Duke University.
Ivan Rusyn
The University of North Carolina at Chapel Hill

Ivan Rusyn is a professor in the Department of Environmental Sciences and Engineering in the School of Public Health at the University of North Carolina (UNC) at Chapel Hill. He directs the Laboratory of Environmental Genomics and the Carolina Center for Computational Toxicology in the Gillings School of Global Public Health at UNC-Chapel Hill. He is a member of the Lineberger Comprehensive Cancer Center, the Center for Environmental Health and Susceptibility, the Bowles Center for Alcohol Studies, and the Carolina Center for Genome Sciences. Dr. Rusyn's laboratory focuses on the mechanisms of action of environmental toxicants, the genetic determinants of the susceptibility to toxicant-induced injury, and computational toxicology. He has served on several National Research Council committees and is currently a member of the Committee on Use of Emerging Science for Environmental Health Decisions and the Committee on Toxicology. Dr. Rusyn received his MD from Ukrainian State Medical University in Kiev and his PhD in toxicology from UNC-Chapel Hill.
Toshihiro Shioda
Massachusetts General Hospital Cander Center

Toshihiro Shioda is an associate professor of medicine at Harvard Medical School and director of the Molecular Profiling Laboratory at Massachusetts General Hospital Cancer Center. Dr. Shioda’s research focuses on the way in which toxic substances in the environment affect the regulation of gene function in the mammalian cells, including stem cells and germ cells. That work has included the use of cutting-edge technologies of genome analysis to determine how environmental endocrine disruptors and other toxins act at the molecular level to disrupt genetic and epigenetic programming in human and mouse cells in live bodies and cell cultures. His laboratory is also exploring the molecular mechanisms of breast cancer resistance to certain anti-estrogen therapies. Dr. Shioda received his MD license in Japan and earned a PhD in biochemistry from Hiroshima University Graduate School of Medicine.

Thomas J. Smith
Harvard School of Public Health

Thomas J. Smith is a professor emeritus at the Harvard School of Public Health. His research interests are in the characterization of environmental and occupational exposures for studies of health effects and the investigation of the relationship between environmental exposure and internal dose. He has developed a toxicokinetic modeling approach for designing exposure evaluations for epidemiologic studies. He is currently using the approach in a cohort study of lung cancer mortality in the United States trucking industry where workers are exposed to diesel exhaust. Dr. Smith is also involved in an exposure study of human metabolism of 1,3-butadiene. He has served as a member of the National Research Council Committee on Human Health Risks of Trichloroethylene and the Panel on Monitoring and the Institute of Medicine Committee on the Assessment of Wartime Exposure to Herbicides in Vietnam. Dr. Smith received a PhD in chemistry and environmental health from the University of Minnesota.
Meir Wetzler
State University of New York

Meir Wetzler is chief of the Division of Leukemia in the Department of Medicine at Roswell Park Cancer Institute, professor of medicine in the School of Medicine and Biomedical Sciences in the State University of New York at Buffalo, and assistant research professor in the Department of Immunology in the Roswell Park Graduate Division State University of New York at Buffalo. Dr. Wetzler’s research interests focus on the role of signal transducer and activation of transcription in leukemogenesis; the cellular and humoral immune response to leukemic-associated antigens; and cytogenetics in acute myeloid leukemia and acute lymphoblastic leukemia. Dr. Wetzler earned an MD from the Hebrew University Hadassah Medical School, Jerusalem, Israel.
Lauren Zeise
Office of Environmental Health Hazard Assessment California Environmental Protection Agency

Lauren Zeise is Deputy Director for Scientific Affairs for the California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA). Dr. Zeise oversees the department’s scientific activities, which include the development of risk assessments, hazard evaluations, toxicity reviews, cumulative impacts analyses, frameworks and methodologies for assessing toxicity and cumulative impact, and the department’s activities in the California Environmental Contaminant Biomonitoring Program. Dr. Zeise was the 2008 recipient of the Society of Risk Analysis’s Outstanding Practitioners Award. She has served on advisory boards and committees of the Environmental Protection Agency, the Office of Technology Assessment, the World Health Organization, and the National Institute of Environmental Health Sciences. Dr. Zeise has served on numerous National Research Council and Institute of Medicine committees. She is currently a member of the Committee on Use of Emerging Science for Environmental Health Decisions and the Committee on Sustainability Linkages in the Federal Government. Dr. Zeise received a PhD in environmental sciences from Harvard University.
Patrick A. Zweidler-McKay
The University of Texas M. D. Anderson Cancer Ctr

Patrick Zweidler-McKay is Section Chief for Pediatric Leukemia and Lymphoma and an associate professor in the Division of Pediatrics at The University of Texas M.D. Anderson Cancer Center. His interests are in developing targeted therapies for children with leukemias and neuroblastoma and his research laboratory is directed at understanding the critical pathways that contribute to leukemia and neuroblastoma. Clinically, he specializes in treating children with particularly difficult or relapsed forms of leukemia and lymphoma, such as infant acute lymphoblastic leukemia and T-cell leukemia/lymphoma. Dr. Zweidler-McKay has previously served as a member of the National Research Committee to Review the Draft IRIS Assessment on Formaldehyde. Dr. Zweidler-McKay earned a PhD in molecular biology and genetics and an MD from Temple University.

Events



Location:

Via Teleconference
Event Type :  
-

Registration for Online Attendance :   
NA

Registration for in Person Attendance :   
NA


If you would like to attend the sessions of this event that are open to the public or need more information please contact

Contact Name:  Ricardo Payne
Contact Email:  rpayne@nas.edu
Contact Phone:  202.334.3982

Agenda
Agenda: This meeting is closed in its entirety.
Supporting File(s)
-
Is it a Closed Session Event?
Yes

Closed Session Summary Posted After the Event

The following committee members were present at the closed sessions of the event:

Alfred O. Berg (chair)
John C. Bailar III
A. Jay Gandolfi
David Kriebel
John B. Morris
Kent E. Pinkerton
Ivan Rusyn
Thomas J. Smith
Meir Wetzler
Lauren Zeise
and Patrick Zweidler-McKay.

The following topics were discussed in the closed sessions:

1) The committee’s draft report.
2) The committee’s conclusions.
3) The project schedule.


The following materials (written documents) were made available to the committee in the closed sessions:

None.

Date of posting of Closed Session Summary:
February 24, 2014
Publication(s) resulting from the event:

-


Location:

National Academy of Sciences Building
2101 Constitution Ave NW, Washington, DC 20418
Event Type :  
-

Registration for Online Attendance :   
NA

Registration for in Person Attendance :   
NA


If you would like to attend the sessions of this event that are open to the public or need more information please contact

Contact Name:  Ricardo Payne
Contact Email:  rpayne@nas.edu
Contact Phone:  202.334.3982

Agenda
This meeting is closed in its entirety.
Supporting File(s)
-
Is it a Closed Session Event?
Yes

Closed Session Summary Posted After the Event

The following committee members were present at the closed sessions of the event:

Alfred O. Berg (chair)
John C. Bailar
A. Jay Gandolfi
David Kriebel
John B. Morris
Kent E. Pinkerton
Ivan Rusyn
Toshihiro Shioda
Thomas J. Smith
Meir Wetzler
Lauren Zeise (via teleconference)
and Patrick Zweidler-McKay.

The following topics were discussed in the closed sessions:

1. Drafts of the committee’s report.
2. The committee’s approach to the statement of task.
3. Committee and staff assignments.
4. Project schedule.


The following materials (written documents) were made available to the committee in the closed sessions:

1. Bankoff, Barbara. Bankoff Associates.
October 10, 2013.
Email to Heidi Murray-Smith, project director and Jim Reisa, board director.
Subject: New paper on N6-formyllysine.
Attachment: Dosimetry of N6-formyllysine adducts following [13C2H2] - formaldehyde exposures in rats.

2. Bankoff, Barbara. Bankoff Associates.
November 13, 2013.
Email to Heidi Murray-Smith, project director and Jim Reisa, board director.
Subject: Risk Assessment Specialty Section (RASS) Webinar: November 13, 2013.

3. Bankoff, Barbara. Bankoff Associates.
December 3, 2013.
Email to Heidi Murray-Smith, project director and Jim Reisa, board director.
Subject: Draft SRA Presentations
Attachments: Epidemiologic Evidence for Formaldehyde as a Human Leukemogen, Integrating Toxicological and Epidemiological Evidence of Carcinogenicity, and Genetic Changes in Circulating Blood Cells.


Date of posting of Closed Session Summary:
December 06, 2013
Publication(s) resulting from the event:

-


Location:

Arnold and Mabel Beckman Center
100 Academy Way, Irvine, CA 92617
Event Type :  
-

Registration for Online Attendance :   
NA

Registration for in Person Attendance :   
NA


If you would like to attend the sessions of this event that are open to the public or need more information please contact

Contact Name:  Ricardo Payne
Contact Email:  rpayne@nas.edu
Contact Phone:  202.334.3982

Agenda
This meeting is closed in its entirety.
Supporting File(s)
-
Is it a Closed Session Event?
Yes

Closed Session Summary Posted After the Event

The following committee members were present at the closed sessions of the event:

Alfred O. Berg (chair)
John C. Bailar
A. Jay Gandolfi
David Kriebel
John B. Morris
Kent E. Pinkerton
Ivan Rusyn
Toshihiro Shioda
Thomas J. Smith
Meir Wetzler
Lauren Zeise
and Patrick Zweidler-McKay (via teleconference).

The following topics were discussed in the closed sessions:

1. Drafts of the committee’s report.
2. The committee’s approach to the statement of task.
3. Assignments, project schedule, and the need for additional background materials and public sessions.


The following materials (written documents) were made available to the committee in the closed sessions:

1. Bankoff, Barbara. Bankoff Associates.
August 8, 2013.
Email to Heidi Murray-Smith, project director.
Subject: Critical Reviews in Toxicology - Analysis of 2010 Zhang et al paper with link to Gentry et al. 2013.

2. Bankoff, Barbara. Bankoff Associates.
July 25, 2013.
Email to Heidi Murray-Smith, project director and Jim Reisa, board director.
Subject: Abstracts for the SRA Session on Formaldehyde Dec. 11, 2013.

3. Bankoff, Barbara. Bankoff Associates.
August 12, 2013.
Email to Heidi Murray-Smith, project director and Jim Reisa, board director.
Subject: Second set of SRA Abstracts for December 10, 2013.


Date of posting of Closed Session Summary:
October 17, 2013
Publication(s) resulting from the event:

-


Location:

Hyatt at Olive 8 Seattle
1635 8th Avenue
Seattle, WA 98101
Event Type :  
-

Registration for Online Attendance :   
NA

Registration for in Person Attendance :   
NA


If you would like to attend the sessions of this event that are open to the public or need more information please contact

Contact Name:  Ricardo Payne
Contact Email:  rpayne@nas.edu
Contact Phone:  202-334-3982

Agenda
This meeting is closed in its entirety.
Supporting File(s)
-
Is it a Closed Session Event?
Yes

Closed Session Summary Posted After the Event

The following committee members were present at the closed sessions of the event:

Alfred O. Berg (chair)
John C. Bailar (via teleconference)
A. Jay Gandolfi
David Kriebel
John B. Morris
Kent E. Pinkerton
Ivan Rusyn
Toshihiro Shioda
Thomas J. Smith
Meir Wetzler
Lauren Zeise
and Patrick Zweidler-McKay.

The following topics were discussed in the closed sessions:

1. The committee’s approach to the statement of task and the report outline.
2. Drafts of the committee’s report.
3. Key studies highlighted in the National Toxicology Program’s assessment of formaldehyde
4. Pertinent literature on formaldehyde that has been identified through literature searches and public access submissions.
5. Assignments, project schedule, and the need for additional background materials and public sessions.


The following materials (written documents) were made available to the committee in the closed sessions:

1. Sass, Jennifer. Natural Resources Defense Council.
5/16/2013
Email via Current Projects System.
Subject: Judge Upholds Styrene Listing in HHS’s “Report on Carcinogens”.
Attachment: Civil Action No. 11-1079 (RBW) Document 56

2. Checkoway, Harvey. University of Washington.
Rodricks, Joseph. ENVIRON.
July 25, 2013.
Letter to Heidi Murray-Smith, project director.
Subject: Request for a Public Meeting of Scientific Experts with the Committee to Review the Formaldehyde Assessment in the NTP 12th RoC.

Date of posting of Closed Session Summary:
August 06, 2013
Publication(s) resulting from the event:

-


Location:

Keck Center
500 5th St NW, Washington, DC 20001
Event Type :  
-

Registration for Online Attendance :   
NA

Registration for in Person Attendance :   
NA


If you would like to attend the sessions of this event that are open to the public or need more information please contact

Contact Name:  Ricardo Payne
Contact Email:  rpayne@nas.edu
Contact Phone:  202.334.3982

Agenda
This meeting is closed in its entirety.
Supporting File(s)
-
Is it a Closed Session Event?
Yes

Closed Session Summary Posted After the Event

The following committee members were present at the closed sessions of the event:

Alfred O. Berg (chair)
A. Jay Gandolfi
David Kriebel
John B. Morris
Kent E. Pinkerton
Ivan Rusyn
Thomas J. Smith
Meir Wetzler
Lauren Zeise
and Patrick Zweidler-McKay.

The following topics were discussed in the closed sessions:

1. Guidelines for effective National Research Council advice.
2. Key studies highlighted in the National Toxicology Program’s assessment of formaldehyde.
3. Sources of pertinent information, including reviewing public access submissions and undertaking a literature search.
4. Report outline and the committee’s approach to the statement of task.
5. Assignments, project schedule, and the need for additional background materials and public sessions.


The following materials (written documents) were made available to the committee in the closed sessions:

1. Sass, Jennifer. Natural Resources Defense Council.
3/21/2013
Email via Current Projects System.
Subject: Copy of article by Jacobs, J.P. 2012. Industry group boosted political spending last year – and it paid off. E&E Publishing. Published February 7, 2012.

2. National Toxicology Program.
4/3/2013
Response to Questions Submitted by NAS.

3. Mundt, Kenneth A. ENVIRON.
4/17/2013
Email to Heidi Murray-Smith, project study director.
Attachments: Comments to NAS Committee - J. Rodricks - 19 Mar 2013, Comments to NAS Committee - C. Ward - 19 Mar 2013.

4. Mundt, Kenneth A. ENVIRON.
4/26/2013
Email to Heidi Murray-Smith, project study director.
Attachment: Rodricks letter to NAS regarding specificity of cancers - April 26 2013.

5. Mundt, Kenneth A. ENVIRON.
4/29/2013
Email to Heidi Murray-Smith, project study director.
Attachment: Letter to NAS regarding Use of Peak Exposure Metric.

6. Risotto, Steve. American Chemistry Council.
5/02/2013
Email to Heidi Murray-Smith, project director.
Subject: NTP’s RoC Review Process


Date of posting of Closed Session Summary:
May 15, 2013
Publication(s) resulting from the event:

-


Location:

Keck Center
500 5th St NW, Washington, DC 20001
Event Type :  
-

Registration for Online Attendance :   
NA

Registration for in Person Attendance :   
NA


If you would like to attend the sessions of this event that are open to the public or need more information please contact

Contact Name:  Ricardo Payne
Contact Email:  rpayne@nas.edu
Contact Phone:  202.334.3982

Agenda


Joint Meeting: Committee to Review the Formaldehyde Assessment in the NTP 12th RoC and the Committee to Review the Styrene Assessment in the NTP 12th RoC

Keck Center of the National Academies
500 5th Street, NW
Washington, DC 20001
Main Meeting - Room 110; Overflow - Room 105*

1:00
Purpose of Public Session and Introduction of Committee Members
Jane Henney, M.D.,
Chair of the Committee to Review the Styrene Assessment in the NTP 12th RoC;
Alfred Berg, M.D., M.P.H.,
Chair of the Committee to Review the Formaldehyde Assessment in the NTP 12th RoC

1:15
Opening Remarks, Study Background, and Study Expectations from the Sponsor
Wanda Jones, Dr.P.H,
Principal Deputy Assistant Secretary for Health,
U.S. Department of Health and Human Services


2:00
Presentation on the Report on Carcinogens
John Bucher, Ph.D.,
Associate Director, National Toxicology Program;
Director, Division of the National Toxicology Program,
National Institute of Environmental Health Sciences,
U.S. Department of Health and Human Services


4:00
Open Microphone – Comments from the Audience

5:30
Adjourn


NOTE: There is limited space and you will need to register in advance to reserve your seat. Please email your contact information to Ricardo Payne at rpayne@nas.edu to register.

* Due to public interest in this meeting and limited space, the main meeting room will be 110 and room 105 will be utilized as an overflow room. A live video of the meeting will be streamed into room 105. Seating is on a first-come, first-served basis.
Supporting File(s)
-
Is it a Closed Session Event?
Yes

Closed Session Summary Posted After the Event

The following committee members were present at the closed sessions of the event:

Alfred O. Berg (chair)
John C. Bailar III
A. Jay Gandolfi
David Kriebel
John B. Morris
Kent E. Pinkerton
Ivan Rusyn
Toshihiro Shioda
Thomas J. Smith
Meir Wetzler
Lauren Zeise (via teleconference)
and Patrick Zweidler-McKay.

The following topics were discussed in the closed sessions:

1) Information presented during the public session.
2) The committee’s statement of task.
3) A draft report outline.
4) Writing assignments.
5) The need for speakers or additional information at future committee meetings.

The following materials (written documents) were made available to the committee in the closed sessions:

1. U.S. Department of Health and Human Services.
1/17/2013
CD containing all references from the background document for the formaldehyde assessment in the NTP 12th Report on Carcinogens.
a. List of references on CD.

2. Risotto, Steve. American Chemistry Council.
1/28/2013
Email to Heidi Murray-Smith, project study director.
Subject: Summary of recent ACC publications discussed with EPA.

3. Wolkoff, Peter. National Research Centre for the Working Environment.
2/19/2013
Email to Heidi Murray-Smith, project study director.
Attachment: Nielsen, G.D., S.T. Larsen, and P. Wolkoff. 2013. Recent trend in risk assessment of formaldehyde exposures from indoor air. Arch Toxicol. 87:73-98.

4. Sass, Jennifer. Natural Resources Defense Council.
2/25/2013
Email via Current Projects System.
Attachment: Center for Effective Government. 2013. Small Businesses, Public Health, and Scientific Integrity: Whose Interests Does the Office of Advocacy at the Small Business Administration Serve?

5. Sass, Jennifer. Natural Resources Defense Council.
2/25/2013
Email via Current Projects System.
Attachment: Center for Progressive Reform. 2013. Distorting the Interests of Small Business: How the Small Business Administration Office of Advocacy’s Politicization of Small Business Concerns Undermines Public Health and Safety.

6. Mundt, Kenneth. ENVIRON; Rodricks, Joseph. ENVIRON; Checkoway, Harvey. University of Washington; Gentry, Robinan. ENVIRON; Boffetta, Paolo. Icahn School of Medicine at Mount Sinai; Mundt, Diane. ENVIRON; Albertini, Richard. University of Vermont; and Irons, Richard. Cinpathogen, Inc. and University of Colorado Anshutz Medical Center.
3/4/2013
Letter to Heidi Murray-Smith , project study director.
Subject: Key areas and issues related to the possible leukemogenicity of formaldehyde.

7. Cox, Tony. Cox Associates and University of Colorado.
3/12/2013
Email to Heidi Murray-Smith, project study director.
Attachment: Cox Jr., L.A. Improving Causal Inferences in Risk Analysis. Forthcoming paper in Risk Analysis.

8. Risotto, Stephen. American Chemistry Council.
3/12/2013
Letter to Alfred Berg, chair of the Committee to Review the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens
Subject: Background information for committee’s Review of the National Toxicology Program’s assessment of formaldehyde.
Attachment: Formaldehyde Science – Response to 2011 NAS Recommendations and References.

9. Risotto, Stephen. American Chemistry Council.
3/12/2013
Letter to Alfred Berg, chair of the Committee to Review the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens
Subject: Unpublished data from NCI-funded studies of formaldehyde.

10. Jones, Wanda. U.S. Department of Health and Human Services.
3/19/2013
PowerPoint presentation to the Committee to Review the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens and the Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens in Washington, DC.
Title: HHS/NAS Contracts to Review Listing for Formaldehyde and Styrene in the 12th Report on Carcinogens.

11. Bucher, John. National Institute of Environmental Health Sciences.
3/19/2013
PowerPoint presentation to the Committee to Review the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens and the Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens in Washington, DC.
Title: Report on Carcinogens Overview.

12. Bucher, John. National Institute of Environmental Health Sciences.
3/19/2013
PowerPoint presentation to the Committee to Review the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens and the Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens in Washington, DC.
Title: 12th RoC Review Process and Listing Criteria.

13. Bucher, John. National Institute of Environmental Health Sciences.
3/19/2013
PowerPoint presentation to the Committee to Review the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens and the Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens in Washington, DC.
Title: Formaldehyde and Styrene Listings.

14. Natural Resources Defense Council.
3/19/2013
Letter to the Committee to Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens and the Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens. Remarks during public comment session.

15. Bus, James, Styron.
3/19/2013
PowerPoint presentation to the Committee to Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens and the Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens in Washington, DC. Presentation during public comment session.
Title: Styrene and Styrene Oxide Animal Data.

16. Collins, James J. Dow Chemical Company.
3/19/2013
PowerPoint presentation to the Committee to Review the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens and the Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens in Washington, DC. Presentation during public comment session.
Title: Presentation to NAS Styrene Committee on Epidemiology.

17. Cruzan, George. Styrene Information and Research Center.
3/19/2013
PowerPoint presentation to the Committee to Review the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens and the Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens in Washington, DC. Presentation during public comment session.
Title: Styrene Mode of Action.

18. Goodman, Julie E. National Marine Manufacturers Association.
3/19/2013
PowerPoint presentation to the Committee to Review the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens and the Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens in Washington, DC. Presentation during public comment session.
Title: Evidence-Based Evaluation of Styrene and Human Cancer.
19. Kearns, Mary. Herban Lifestyle.
3/19/2013
Letter to the Committee to Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens and the Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens. Remarks during public comment session.

20. Scranton, Alexandra. Women's Voices for the Earth.
3/19/2013.
Email via Current Projects System.
Subject: Comments on review of styrene and formaldehyde assessments

21. Risotto, Steve, American Chemistry Council.
3/19/2013
PowerPoint slide to the Committee to Review the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens and the Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens in Washington, DC. Presented during public comment session.
Slide Subject: NPC - NCI’s Highest Peak Exposure Association Driven by Plant 1.

22. Collins, James. Dow Chemical Company.
3/20/2013
Email to Heidi Murray Smith, project study director.
Attachment: Collins and Bodner (2012). Cancer Mortality of Workers Exposed to Styrene in the US Reinforced Plastics and Composite Industry.

23. Risotto, Steve. American Chemistry Council
3/20/2013
Email to Heidi Murray-Smith, project study director.
Attachment: ACC’s Formaldehyde Panel Comments for the NAS RoC Committee.

Date of posting of Closed Session Summary:
March 26, 2013
Publication(s) resulting from the event:

-


Location:

Teleconference
Event Type :  
-

Registration for Online Attendance :   
NA

Registration for in Person Attendance :   
NA


If you would like to attend the sessions of this event that are open to the public or need more information please contact

Contact Name:  Ricardo Payne
Contact Email:  rpayne@nas.edu
Contact Phone:  202.334.3982

Agenda
This meeting is closed in its entirety.
Supporting File(s)
-
Is it a Closed Session Event?
Yes

Closed Session Summary Posted After the Event

The following committee members were present at the closed sessions of the event:

Alfred O. Berg (chair)
John C. Bailar III
A. Jay Gandolfi
David Kriebel
John B. Morris
Kent E. Pinkerton
Ivan Rusyn
Toshihiro Shioda
Thomas J. Smith
Meir Wetzler
Lauren Zeise
and Patrick Zweidler-McKay.

The following topics were discussed in the closed sessions:

1) The committee’s bias and conflict of interest discussion.
2) Logistics in preparation for the March 19-20 committee meeting.


The following materials (written documents) were made available to the committee in the closed sessions:

None.

Date of posting of Closed Session Summary:
February 21, 2013
Publication(s) resulting from the event:

-

Publications

  • Publications having no URL can be seen at the Public Access Records Office