Date:  March 29, 2012




Report Presents Designs for Study of Cancer Risks Near U.S. Nuclear Facilities; Pilot Study Would Assess Feasibility


WASHINGTON -- A proposed study could help determine if there is a link between living near nuclear power plants or other nuclear facilities and having a higher risk of cancer, but challenges and limitations exist, says a new report from the National Research Council, the operating arm of the National Academy of Sciences and National Academy of Engineering.  The report recommends that a pilot study be completed first to evaluate the feasibility of a full-scale study, although the ultimate decision about whether to perform either would be the responsibility of the U.S. Nuclear Regulatory Commission (USNRC), which sponsored the Research Council report. 


The first phase of a two-phase project, the report identifies scientific approaches for carrying out an assessment of cancer risks for populations near the 104 nuclear reactors and 13 fuel cycle facilities that the USNRC licenses across the U.S. as well as for people who have lived close to former sites.  The USNRC requested the report because it has been using the results of a 1990 National Cancer Institute survey as its primary public resource about cancer risks near its nuclear facilities, and that study is now outdated and has limitations.


"Finding scientific evidence of whether people who live near nuclear facilities have a greater risk of developing cancer than those who live farther away is a challenge," said John Burris, chair of the committee that wrote the report and president of Burroughs Wellcome Fund in Research Triangle Park, N.C.  "There are issues of whether scientists can get the information needed to carry out the study.  For example, some state cancer registries have only recently attained quality data.  Also, data may be insufficient to estimate the amount of radioactive material released from nuclear facilities, especially during early years of operations.  This makes it much more difficult to determine risks from decades ago when radiation releases from nuclear facilities were larger." 


The committee recommended two approaches to the cancer risk study, which could be carried out by the Research Council as the second phase of its project, should the USNRC decide to proceed.  One approach would be to investigate rates of cancer occurrence and cancer deaths in small geographic areas within approximately a 30-mile radius of nuclear facilities.  The different geographic areas should represent a range of potential exposures from radioactive material releases from the facilities, from the highest to essentially no exposure.  Another would be to conduct a record-based, case-control study to assess the association of cancers in children less than 15 years old in relation to their mothers' residential proximity to a nuclear facility during pregnancy.  Both approaches would have a sub-analysis focusing on leukemia, the cancer associated with radiation exposure in children.


The committee listed several challenges to carrying out the study, including uneven availability and quality of data on cancer mortality and incidence at geographic levels smaller than the county level and uneven availability of data on the amount of radiation released from nuclear facilities.  There also may be limited information on population mobility and potential confounding factors, including exposure to cigarette smoke, access to health care, contact with toxic chemicals, and exposure to other sources of radiation such as from medical procedures like CT scans.  The impact of these other possibly immeasurable factors on cancer incidence and mortality could overwhelm the expected effect from the releases of radiation from nuclear facilities.  Moreover, the doses resulting from monitored and reported radioactive releases from nuclear facilities are expected to be low.  Therefore the cancer risks, if any, are likely small.  It is not certain whether a full-scale study would have sufficient statistical power to detect such small effects, if present. 


Given these challenges, if the USNRC decides to move forward with the cancer risk study, the committee proposed a pilot study to verify whether the two recommended approaches could be conducted on a large scale and to help estimate the necessary time, costs, and resources.  The committee suggested that the pilot study focus on six nuclear power plants and one fuel cycle facility that provide a broad representation of plant designs and operating histories: Dresden, Ill.; Millstone, Conn.; Oyster Creek, N.J.; Haddam Neck, Conn.; Big Rock Point, Mich.; San Onofre, Calif.; and Nuclear Fuel Services, Tenn.


If such a study goes forward, it is essential that the USNRC communicate with and involve the public and other stakeholders in order to broaden acceptance of the results, the report stresses.  A plan for stakeholder engagement should be developed prior to the initiation of data gathering and analysis, and it should include processes to identify key stakeholders, assess their perceptions and concerns, communicate the questions that the study would address and its strengths and limitations, and make the data used in the study publicly accessible to the extent possible.


The study was sponsored by the U.S. Nuclear Regulatory Commission.  The National Academy of Sciences, National Academy of Engineering, Institute of Medicine, and National Research Council make up the National Academies.  They are independent, nonprofit institutions that provide science, technology, and health policy advice under an 1863 congressional charter.  Panel members, who serve pro bono as volunteers, are chosen by the Academies for each study based on their expertise and experience and must satisfy the Academies' conflict-of-interest standards.  The resulting consensus reports undergo external peer review before completion.  For more information, visit  A committee roster follows.



Jennifer Walsh, Media Relations Officer

Luwam Yeibio, Media Relations Assistant

Office of News and Public Information

202-334-2138; e-mail



Pre-publication copies of ANALYSIS OF CANCER RISKS IN POPULATIONS NEAR NUCLEAR FACILITIES: PHASE 1 is available from the National Academies Press; tel. 202-334-3313 or 1-800-624-6242 or on the Internet at  Reporters may obtain a copy from the Office of News and Public Information (contacts listed above).


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Division on Earth and Life Studies

Nuclear and Radiation Studies Board


Committee on the Analysis of Cancer Risks in Populations Near Nuclear Facilities: Phase 1


John E. Burris (chair)


Burroughs Wellcome Fund

Research Triangle Park, N.C.


John C. Bailar III1

Professor Emeritus

Department of Health Studies

University of Chicago (retired)

Washington, D.C.


Harold L. Beck


Environmental Measurements Laboratory

U.S. Department of Energy (retired)

New York City


Andre Bouville

Senior Radiation Physicist

Radiation Epidemiology Branch

National Cancer Institute (retired)

Bethesda, Md.


Phaedra S. Corso


Department of Health Policy and Management

College of Public Health

University of Georgia



Patricia J. Culligan


Civil Engineering and Engineering Mechanics

Columbia University

New York City


Paul M. DeLuca Jr.

Professor, and

Provost and Vice Chancellor for Academic Affairs

Department of Medical Physics

University of Wisconsin



Raymond A. Guilmette


Center for Countermeasures Against Radiation

Lovelace Respiratory Research Institute

Albuquerque, N.M.


George M. Hornberger2


Vanderbilt Institute for Energy and Environment,

Nashville, Tenn.


Margaret R. Karagas

Head Section of Biostatistics and Epidemiology

Dartmouth College

Lebanon, N.H.


Roger E. Kasperson3

Research Professor and Distinguished Scientist

The George Perkins Marsh Institute

Clark University (retired)

Washington, D.C.


James E. Klaunig

Professor and Director

Department of Pharmacology and Toxicology

Indiana University



Timothy Mousseau

Professor of Biological Sciences

University of South Carolina



Sharon Murphy

Founding Director

Greehey Children's Cancer Research Institute

University of Texas Health Science Center (retired)

Washington, D.C.


Roy E. Shore

Vice Chairman and Chief of Research

Radiation Effects Research Foundation




Daniel O. Stram


Department of Preventive Medicine

University of Southern California

Los Angeles


Margot Tirmarche


Ionizing Radiation Epidemiology Laboratory

Institute for Radiological Protection and Nuclear Safety

Fontenay-aux-Roses, France


Lance A. Waller


Department of Biostatistics

Rollins School of Public Health

Emory University



Gayle E. Woloschak


Department of Radiation Oncology

Northwestern University


Jeffrey J. Wong

Deputy Director

Office of Pollution Prevention and Technology Development

Department of Toxic Substances Control

California Environmental Protection Agency





Kevin Crowley

Study Director

Ourania Kosti

Program Officer 


1          Member, Institute of Medicine

2          Member, National Academy of Engineering

3          Member, National Academy of Sciences