Unraveling Low Dose Toxicity: Case Studies of Systematic Review of Evidence

Emerging evidence suggests chemicals such as endocrine disruptors have effects at doses even lower than those used in traditional toxicity testing performed by the U.S. Environmental Protection Agency (EPA), raising concerns about the adequacy of current testing practices.

A new report by the National Academies of Sciences, Engineering, and Medicine develops a strategy to evaluate the evidence for adverse human health effects from endocrine-disrupting chemicals at lower doses. The report also details findings of systematic reviews of animal and human studies on two chemicals conducted by the study committee, demonstrating how the results can be integrated and considered with other relevant data to draw conclusions about causal associations.

Advance copies of Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity From Endocrine Active Chemicals will be available to reporters only beginning at noon EDT on Monday, July 17.  The report is embargoed and not for public release before 2 p.m. EDT on Tuesday, July 18.  To obtain a copy of the report, reporters should contact the Academies’ Office of News and Public Information; tel. 202-334-2138 or email news@nas.edu.