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Date: July 24, 2009
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Luwam Yeibio, Media Relations Assistant
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FOR IMMEDIATE RELEASE
Limited Data Suggest Possible Association Between Agent Orange Exposure and
Ischemic Heart Disease and Parkinson's Disease in
A finding of "limited or suggestive evidence of an association" means that the evidence indicates there could be a link between exposure to a chemical and increased risk for a particular health effect, though conflicting results from studies, problems with how the studies were conducted, or other confounding factors limit the certainty of the evidence. Until now, the cumulative evidence had been inadequate to draw conclusions about whether these two conditions may be associated with veterans' exposures to herbicides or TCDD.
Ischemic heart disease -- a condition characterized by reduced blood supply to the heart, which can lead to heart attack and stroke -- is the foremost cause of death among people in industrialized countries. Major risk factors include buildup of cholesterol in the arteries, age, smoking, high blood pressure, and diabetes. The committee that wrote the report reviewed several studies investigating TCDD exposure and heart disease, many of which showed that higher TCDD exposure correlated with greater incidence of disease. The studies had weaknesses; for instance, it is difficult to adjust entirely for the impact of smoking, age, weight, and other common risk factors. But based on the preponderance of the evidence as well as biologic data beginning to show how TCDD can cause this toxic effect, the committee concluded that the evidence suggests that veterans exposed to defoliants contaminated with TCDD during the war may face a higher risk for developing ischemic heart disease.
The committee's conclusion that there may be a relationship between Parkinson's disease and Agent Orange exposure stems from its review of 16 studies that looked at herbicide exposures among people with Parkinson's disease or Parkinson's-like symptoms. The finding was bolstered by several studies that have identified exposure to certain compounds similar to those in the herbicides used in the war as potential risk factors for the development of Parkinson's. The committee's review was hampered by the lack of studies investigating the occurrence of Parkinson's disease in
In response to a request for clarification by the U.S. Department of Veterans Affairs, the committee also affirmed that hairy cell leukemia is in the same category as chronic lymphocytic leukemia (CLL) and lymphomas. Previous reviews in the series found sufficient evidence to state that there is an association between herbicide exposure and increased risk for CLL and lymphomas.
The report presents scientific data only and does not suggest or intend to imply policy decisions that the U.S. Department of Veterans Affairs might make. Also, the findings relate to exposures and outcomes in broad populations; researchers' abilities to pinpoint the health risks faced by any individual veteran are hindered by inadequate information about military personnel's exposure levels during service in
The report series is sponsored by the U.S. Department of Veterans Affairs. Established in 1970 under the charter of the National Academy of Sciences, the
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[ This news release and report are available at http://national-academies.org ]
Board on Population Health and Public Health Practice
Committee to Review the Health Effects in
Seventh Biennial Update
Richard A. Fenske, Ph.D., M.P.H. (chair)
Erin M. Bell, Ph.D.
Department of Epidemiology and Biostatistics
Scott W. Burchiel, Ph.D.
Professor and Associate Dean for Research
Janice E. Chambers, Ph.D.
Professor of Biostatistics in Psychiatry
Peter H. Gann, M.D., Sc.D.
Professor and Director of Pathology Research
Mark S. Goldberg, Ph.D.
Division of Epidemiology and Biostatistics
Department of Medicine
Professor of Environmental and Molecular Toxicology
Associate Professor, and
Director of Graduate Studies
Department of Epidemiology
Alvaro Puga, Ph.D.
Professor of Molecular Biology and Environmental Health, and
Superfund Basic Research Program
Jeremy M. Shefner, M.D., Ph.D.
Professor and Chair
Department of Neurology
Associate Professor of Molecular and Biomedical Pharmacology
Mary Paxton, Ph.D.