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Project Title:
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Sequel to Assessment of Future Scientific Needs for Live Variola Virus
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PIN:
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BOGH-H-07-05-A
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Major Unit:
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Institute of Medicine
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Sub Unit:
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Board on Global Health
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RSO:
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Kelley, Patrick
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Subject/Focus Area:
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Project Scope
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An ad hoc committee of the Institute of Medicine shall conduct a study on the
continued use of live variola virus stocks for research and public health purposes.
In follow-on to the IOM's 1999 report, Assessment of Future Scientific Needs for Live
Variola Virus, an IOM committee will perform a comprehensive evaluation of the research and development work recommended in that report and completed to date, and
consider what unmet needs still exist that require the use of live variola virus. The conclusions and recommendations will inform policy discussions in the
U.S. and within the world community regarding the continued need to retain the official
stocks of live variola virus for research purposes, and would provide a major review of
completed, ongoing and planned research activities that should be undertaken.
The committee shall specifically consider and offer recommendations pertinent
to the utility of live variola virus in addressing potential unmet requirements including:
1. Advanced development through licensure and post-licensure of antivirals for use in
treatment of variola virus infections.
2. Advanced development through licensure and post-licensure of new, safe and effective
vaccine(s).
3. Development through licensure and post-licensure of less-reactogenic vaccines.
4. Development of approved protein-based diagnostics which can be used in field
situations or diagnostics which have sources of error distinct from those of nucleic
acid-based diagnostics.
5. Improved pathogenesis data to drive therapeutic discovery.
The project is sponsored by the Centers for Disease Control and Prevention.
The approximate start date for the project is September 1, 2007 to September 30, 2009.
A report will be issued at the end of the project in approximately 15 months
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Project Duration:
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15 months
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Provide FEEDBACK on this project.
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Tel:
202.334.2000