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Project Title:

Incorporating 21st Century Science into Risk-Based Evaluations
PIN: DELS-BEST-14-04        

Major Unit:

Division on Earth and Life Studies

Sub Unit: Board on Life Sciences
Board on Environmental Studies & Toxicology

RSO: Mantus, Ellen

Subject/Focus Area: Environment and Environmental Studies

Project Scope
A ad hoc committee under the auspices of the National Research Council (NRC) will provide recommendations on integrating new scientific approaches into risk-based evaluations.  Specifically, the committee will first consider the scientific advances that have occurred following the publication of the NRC reports Toxicity Testing in the 21st Century: A Vision and a Strategy and Exposure Science in the 21st Century: A Vision and a Strategy.  Given the various ongoing lines of investigation and new data streams that have emerged, the committee will then propose how best to integrate and use the emerging results in evaluating chemical risk and identify how traditional human-health risk assessment can incorporate the new science.   It will consider whether a new paradigm is needed for data validation (or acceptance), how to integrate the divergent data streams, how uncertainty might need to be characterized (or how characterization of uncertainty might need to change), and how best to communicate the new approaches so that they are understandable to various stakeholders.  It will focus its recommendations on pragmatic solutions and provide case studies that illustrate its recommendations.  Finally, the committee will identify barriers or obstacles to advancing and integrating the various types of science, and ultimately transforming risk assessment.

Project Duration: 24 months    

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Committee Membership
Committee Membership

 Meeting 1 - 01/26/2014
 Meeting 2 - 04/01/2015
 Meeting 3 - 06/04/2015
 Meeting 4 - 09/24/2015
 Meeting 5 - 12/14/2015
 Meeting 6 - 02/11/2016
 Meeting 7 - 05/23/2016


Reports having no URL can be seen
at the Public Access Records Office