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Project Title:

Design and Evaluation of Safer Chemical Substitutions – A Framework to Inform Government and Industry Decisions
PIN: DELS-BCST-13-02        

Major Unit:

Division on Earth and Life Studies

Sub Unit: Board on Chemical Sciences and Technology

RSO: Shelton-Davenport, Marilee

Subject/Focus Area: Biology and Life Sciences; Environment and Environmental Studies; Math, Chemistry and Physics

Project Scope
An ad hoc committee shall develop and demonstrate a decision framework for evaluating potentially safer substitute chemicals as determined by human health and ecological risks. The committee shall identify the scientific information and tools required by regulatory agencies and industry to improve and increase consideration of potential health and environmental impacts early in the chemical design process. The decision framework shall be capable of integrating multiple and diverse data streams to support early consideration of potential health and environmental impacts as a part of fit-for-purpose decision making.

The framework shall discuss how risk (hazard and potential for human exposure and toxicity) and environmental impact (ecological risks) can be characterized for chemical substitutions within the context of the full range of benefits and shortcomings of substitutes, and how tradeoffs between these risks and factors such as product functionality, product efficacy, process safety and resource use can be quantified.

In its report, the committee shall describe the framework and provide at least two examples that demonstrate how the framework can be applied by different users in contrasting decision contexts with diverse priorities. These examples shall include demonstration of how high throughput and high content data streams could inform assessment of potentially safer substitutes early in the chemical development process.

The project is sponsored by the Environmental Protection Agency (EPA).

The start date for this project is July 12, 2013. A report is expected to be issued in spring 2014.

Project Duration: 14 months    

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Committee Membership
Committee Membership

 Meeting 1 - 09/17/2013
 Meeting 2 - 09/20/2013
 Meeting 3 - 11/15/2013
 Meeting 4 - 12/16/2013
 Meeting 5 - 01/04/2014
 Meeting 6 - 02/06/2014
 Meeting 7 - 05/08/2014
 Meeting 8 - 10/24/2014


Reports having no URL can be seen
at the Public Access Records Office
A Framework to Guide Selection of Chemical Alternatives