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Project Title:

Development of a Case Definition for Chronic Multisymptom Illness
PIN: IOM-BSP-12-07        

Major Unit:

Institute of Medicine

Sub Unit: Board on the Health of Select Populations

RSO: Fulco, Carolyn

Subject/Focus Area: Health and Medicine


Project Scope
An ad hoc committee will develop a consensus case definition for chronic multisymptom illness (CMI) as it pertains to the 1990-91 Gulf War Veteran population.  The committee will comprehensively review, evaluate, and summarize the available scientific and medical literature regarding symptoms for CMI among the 1991 Gulf War Veterans. The committee will look broadly for relevant information, including, but not limited to:

1. Published peer-reviewed literature concerning existing case definitions for CMI among the 1990-1991 Gulf War Veteran population;
 2. Published peer-reviewed literature concerning existing case definitions of CMI among similar populations such as Allied military personnel; and
3. Published peer-reviewed literature concerning case definitions for other populations with a similar constellation of symptoms. 
4.  Discussions with researchers involved with developing case definitions for chronic multisymptom illness in 1990-1991 Gulf War Veterans.
5.  Discussions with clinicians who treat veterans of the 1990-1991 Gulf War.

In addition to reviewing and summarizing the available scientific and medical literature regarding symptoms and case definitions for CMI among Gulf War Veterans, the committee will:

1. Establish a consensus case definition along with guidelines for its use.
2. Evaluate existing case definitions in relation to priorities identified by the committee and determine whether an existing case definition is adequate, an existing case definition needs to be revised, or a new case definition needs to be established.
3 Consider issues such as specificity (the degree to which the definition applies to 1990-1991 Gulf War Veterans), sensitivity (the degree to which the case definition captures the excess  symptomatology in 1990-1991 Gulf War Veterans), reliability ( the degree to which Veterans’ symptoms are determined in a consistent manner), and portability (the degree to which the case definition is suitable for use in different study designs) in evaluating case definitions.
4. Consider the potential for the case definition, optimized for research purposes, to be used in clinical practice.
5. Consider other case definition characteristics deemed important.
6.  Recommend addiitonal areas of research or study that may be required to more adequately develop a consensus definition for chronic multisymptom illness.
6. Evaluate the terminology currently used in referring to CMI in 1990-1991 Gulf War Veterans and recommend appropriate terminology for the CMI in 1990-1991 Gulf War Veterans.

The project is sponsored by U.S. Department of Veterans Affairs.

The approximate start date for the project is May 1, 2013.

A report will be issued at the end of the project in approximately 12 months.


 
Project Duration: 12 months    

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Contact the Public Access Records Office to make an inquiry, request a list of the public access file materials, or obtain a copy of the materials found in the file.


Committee Membership
Committee Membership

Meetings
 Meeting 1 - 06/26/2013
 Meeting 2 - 08/14/2013
 Meeting 3 - 10/30/2013
 Meeting 4 - 12/11/2013

Reports

Reports having no URL can be seen
at the Public Access Records Office
Chronic Multisymptom Illness in Gulf War Veterans: Case Definitions Reexamined