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Project Title:

Review of the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens
PIN: DELS-BEST-12-05        

Major Unit:

Division on Earth and Life Studies

Sub Unit: Board on Environmental Studies & Toxicology

RSO: Murray-Smith, Heidi

Subject/Focus Area: Environment and Environmental Studies

Project Scope

A committee of the National Research Council (NRC) will conduct a scientific peer review of the styrene assessment presented in the National Toxicology Program (NTP) 12th Report on Carcinogens (RoC). The committee will identify and evaluate relevant, publicly available, peer-reviewed literature, with particular emphasis on literature published as of June 10, 2011, the release date of the 12th RoC. The committee will document its decisions for inclusion or exclusion of literature from its evaluation and will identify the set of information deemed most critical to the evaluation. The committee will apply independently the NTP’s established RoC listing criteria to the scientific evidence from studies in humans, experimental animals, and other studies relevant to mechanisms of carcinogenesis and make independent level-of-evidence determinations with respect to the human and animal studies. The committee will integrate the level-of-evidence conclusions, and considering all relevant information in accordance with the RoC listing criteria, make an independent listing recommendation for styrene and provide scientific justification for its recommendation.

Note: The NRC has an agreement with the Department of Health and Human Services to undertake a scientific peer review of the determinations concerning formaldehyde and styrene in the National Toxicology Program’s 12th Report on Carcinogens (RoC). The expert committees appointed by the Academy for this assignment will follow standard Academy practices in carrying out their independent scientific reviews, which may include consideration of any and all issues that the committees and the Academy decide are necessary to carry out credible, independent, scientific evaluations of the two determinations, potentially including the criteria for the determinations. The statements of task for these two peer reviews were recently modified to make it clear that the NRC’s assignment does not also include a separate review of the National Toxicology Program’s listing criteria.

The project is sponsored by the Department of Health and Human Services.

The approximate start date for the project is 09/10/2012.

A final report will be issued at the end of the project in approximately 24 months.

Project Duration: 24 months    

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Committee Membership
Committee Membership

 Meeting 1 - 02/19/2013
 Meeting 2 - 03/19/2013
 Meeting 3 - 05/13/2013
 Meeting 4 - 08/26/2013
 Meeting 5 - 11/04/2013
 Meeting 6 - 01/14/2014
 Meeting 7 - 03/18/2014


Reports having no URL can be seen
at the Public Access Records Office
Review of the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens