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Project Title:

Guidance for and Review of EPA's IRIS Toxicological Assessment of Inorganic Arsenic
PIN: DELS-BEST-12-01        

Major Unit:

Division on Earth and Life Studies

Sub Unit: Board on Environmental Studies & Toxicology

RSO: Martel, Susan

Subject/Focus Area: Environment and Environmental Studies; Policy for Science and Technology

Project Scope
An ad hoc committee will plan and conduct a public workshop to evaluate critical scientific issues in assessing cancer and noncancer effects from oral exposure to inorganic arsenic.  Informed by the workshop, the committee will prepare an interim report providing recommendations on how those issues can be addressed in EPA's IRIS assessment.  After EPA has revised the IRIS assessment, the committee will review it to determine whether the scientific literature on inorganic arsenic was adequately evaluated, whether appropriate methods were used to derive cancer risk estimates and noncancer reference values, and whether dose-response relationships between inorganic arsenic and cancer and noncancer effects were appropriately estimated and characterized.  As requested by Congress, the committee will also determine whether the arsenic document reflects recommendations made in Chapter 7 of the 2011 NRC report on formaldehyde for improving descriptions of methods and criteria for selecting studies, approaches to evaluating critical studies, weight-of-evidence analyses, and justification of modeling approaches in IRIS assessments.  The workshop will enable the committee to gather a variety of perspectives from stakeholders and others on the issues.

The project is sponsored by the U.S. Environmental Protection Agency.

The approximate start date for the project is July 17, 2012.

An interim report will be issued following completion of the public workshop. A final report will be issued at the end of the project.

Project Duration: 41 months    

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Committee Membership
Committee Membership

 Meeting 1 - 01/24/2013
 Meeting 2 - 04/04/2013
 Meeting 3 - 05/29/2013
 Meeting 4 - 12/02/2015


Reports having no URL can be seen
at the Public Access Records Office
Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic: Interim Report