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Project Title:
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Animal Models for Assessing Countermeasures to Bioterrorism Agents
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| PIN:
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ILAR-K-08-02-A
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Major Unit:
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Division on Earth and Life Studies
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Sub Unit:
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Board on Life Sciences
Institute for Laboratory Animal Research
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RSO:
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Anestidou, Lida
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Subject/Focus Area:
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Animal Models for Assessing Countermeasures to Bioterrorism Agents
November 15, 2009 - November 17, 2009
Keck Center
500 5th Street, NW
Washington D.C. 20001
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If you would like to attend the sessions of this meeting that are open
to the public or need more information please contact:
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| Contact Name:
Kathy Beil
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| Email:
kbeil@nas.edu
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| Phone:
202-334-1264
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Fax:
202-334-1687
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Agenda:
ANIMAL MODELS FOR ASSESSING COUNTERMEASURES
TO BIOTERRORISM AGENTS
Committee Meeting: November 15-17, 2009
Keck Center, 500 Fifth Street NW, room 110
AGENDA
Date: Sunday, November 15, 2009
OPEN Data Gathering Session: 1:30 – 3:30 pm
2.1 GLP studies
1:30 – 2:30 pm Dr. Louise Pitt, Director, Center for Aerobiological Sciences, USAMRIID
GLP studies in biocontainment: Toward Animal Rule licensure_Issues, challenges and humane endpoints
2.2 Alternatives I
2:30 – 3:30 pm Dr. Thomas Hartung, Director, Center for Alternatives to Animal Testing, Johns Hopkins
Definition and validation of alternative models
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Date: Monday, November 16, 2009
OPEN Data Gathering Session: 9:00 am – 6:30 pm
2.1 Computational Systems Analysis
9:00 – 10:00 am Dr. Kenneth Drake, CEO, Seralogix
In silico approaches to disease modeling
10:00 - 11:00 am Dr. Rui-Ru Ji, Bristol-Myers Squibb
Transcriptional dose-response profiling
11:00 – 11:15 am Break
2.2 Telemetry
11:15 am - 12:15 pm Dr. Lisa Hensley, Chief Viral Therapeutics, Virology Division, USAMRIID
Telemetry uses in BSL facilities and clinical trials
12:15 – 1:45 pm
• Mr. Robert Brockway, Director Product Marketing, Data Sciences International
Advanced telemetry methods in the context of the Animal Rule
and
Respiration and safety pharmacology translational models
• Dr. Russell Bialecki, Director, Safety Pharmacology North America, Astra Zeneca
Automated PK/PD and metabolic analysis integration with chronic telemetric monitoring in rodent models
2.3 1:45 – 2:15 pm Working lunch
2.4 Surrogate markers/Biomarkers I
2:15 – 3:15 pm Dr. Steven Opal, Director, Infectious Diseases Division, Memorial Hospital of Rhode Island
Surrogate markers in translational research (where animal to human translation is not an option)
3:15 – 4:15 pm Dr. Donald Low, Microbiologist-in-Chief, Mount Sinai Hospital, Toronto, Canada
Surrogate markers as decision-making tools in clinical medicine
4:15 – 4:30 pm Break
2.5 Imaging
4:30 – 5:30 Dr. Charles Lin, Wellman Center for Photomedicine, Massachusetts General Hospital
Non-biocontainmnet imaging in the context of Animal Rule requirements
5:30 – 6:30 pm Dr. Peter Jahrling, Director, NIAID Integrated Research Facility and
Dr. Daniel Mollura, Staff Clinician, NIH Clinical Center, and Staff Scientist, NIAID Integrated Research Facility
Medical imaging in biocontainment in the context of Animal Rule requirements
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Date: Tuesday, November 17, 2009
OPEN Data Gathering Session: 9:00 – 11:00 am
2.1 Surrogate markers/Biomarkers II
9:00 - 10:00 am Dr. Bruce Aronow, Scientific Director, Center for Computational medicine, University of Cincinnati College of Medicine
Virulence networks’ detection and host defense interaction
2.2 Alternatives II
10:00 - 11:00 am Dr. Steve Niemi, Director, Center for Comparative Medicine, Massachusetts General Hospital
The animal as patient: The ICU approach to animal research subjects
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Closed Session Summary Posted After the Meeting
The following committee members were present at the closed sessions of the meeting:
Korch
Niemi (on 11/16 and 11/17/2009)
Bergman
Ehrlich
Goldenthal (on 11/15/2009)
Hartung
Heitman (via teleconference on 11/15 and 11/17/2009)
Kotb
Kuhn
Lyons
Morse
Murphy
Patel
Swearengen (on 11/16 and 11/17/2009)
The following topics were discussed in the closed sessions:
Committee members' presentations
Conflict of Interest and bias
Committee expertise
Report outline, writing assignments
Preparation of next meeting
The following materials (written documents) were made available to the committee in the closed sessions:
Committee members' presentations
Date of posting of Closed Session Summary:
November 20, 2009
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